Int. J. of Nanomanufacturing   »   2014 Vol.10, No.1/2

 

 

Title: Preparation and characterisation of magnetic mesoporous silica with a large pore size

 

Authors: Yan Shan; Xuegang Yu; Yangqiao Liu; Kezheng Chen

 

Addresses:
College of Materials Science and Engineering, Qingdao University of Science and Technology, 53 Zhengzhou Road, Qingdao 266042, China
College of Materials Science and Engineering, Qingdao University of Science and Technology, 53 Zhengzhou Road, Qingdao 266042, China
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, China
College of Materials Science and Engineering, Qingdao University of Science and Technology, 53 Zhengzhou Road, Qingdao 266042, China

 

Abstract: A new kind of magnetic mesoporous nanoparticle composed of a uniform Fe3O4 nanoscale core and a larger pore size of SiO2 mesoporous shell (Fe3O4@meso-SiO2) has been successfully synthesised in a water/oil phase. The obtained core-shell structure is less than 100 nm in diameter and the pore size of mesoporous SiO2 layer is about 7 to 12 nm, which can be controllable through variation of styrene content. The magnetic property, drug delivery, magnetic resonance, and their in vitro c to HeLa cells were evaluated. The results showed that the magnetic mesoporous silica maintained superparamagnetic behaviour at room temperature, and possessed good transverse relaxivity and good biocompatibility. Additionally, the drug loading and release test indicated that the loading efficiency of DOX was 92%, and the Fe3O4@meso-SiO2 system showed a sustained-release property. The materials have great potential application for simultaneous MRI contrast T2 agent and targeting drug-delivery technology.

 

Keywords: magnetic mesoporous silica; pore size; drug delivery; styrene content; nanoparticles; nanotechnology; magnetic properties; magnetic resonance; superparamagnetic behaviour; transverse relaxivity; biocompatibility.

 

DOI: 10.1504/IJNM.2014.059003

 

Int. J. of Nanomanufacturing, 2014 Vol.10, No.1/2, pp.120 - 131

 

Submission date: 21 Jan 2013
Date of acceptance: 26 Mar 2013
Available online: 01 Feb 2014

 

 

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