Title: The significance of molecular mechanics property to protein evolution

Authors: Li-Mei Zhang; Xin Liu

Addresses: School of Science, Beijing Jiaotong University, Beijing 100044, China ' The State Key laboratory of Nonlinear Mechanics, Institute of Mechanics, Chinese Academy of Sciences, No. 15 Beisihuanxi Road, Beijing 100190, China

Abstract: In the study of protein homology, multiple physical systems that correspond to different proteins must be jointly considered, such that the similarity of homologs can be explained in an aspect of the physics. Compared with the investigations that focus on the character of certain protein, the research object changes from one physical system to a set of systems. For this enlarged object, the importance of different physical quantities is still unclear. In an aspect of hydrophobic interaction, we rank the significance of different physical quantities here, according to their contribution to the conservation of family representative biological properties in protein evolution. Molecular mechanics property is suggested to be the governing factor responsible for protein homology.

Keywords: hydrophobic interaction; protein evolution; molecular mechanics; protein homology; bioinformatics.

DOI: 10.1504/IJDMB.2013.054698

International Journal of Data Mining and Bioinformatics, 2013 Vol.8 No.1, pp.83 - 91

Received: 16 Sep 2010
Accepted: 03 Oct 2011

Published online: 20 Oct 2014 *

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