Title: Genome-wide identification and evolutionary analysis of B7-H3

Authors: Hairong Duan; Moli Huang

Addresses: Center for System Biology, Soochow University, Suzhou, 215006, China ' Center for System Biology, Soochow University, Suzhou, 215006, China

Abstract: B7-H3 is an immune co-stimulatory molecule of the B7 family that contains a set of immunoglobulin-V (IgV) and immunoglobulin-C (IgC) domains. To explore the evolutionary process of B7-H3 gene, we conducted a genome-wide structure and phylogenetic analysis of B7-H3 genes in currently sequenced genomes. On the basis of the available data, 17 mammalian B7-H3 genes were predicted to have tandemly duplicated 4Ig domains. The analysis of gene structure and phylogenesis reveal that these 4IgB7-H3 genes resulted from domain duplication. Nevertheless, no difference in function has been observed between the two isoforms. It is more likely that domain duplication in 4IgB7-H3 leads to functional redundancy.

Keywords: B7; gene structure; exon duplication; phylogenetic analysis; bioinformatics; immune co-stimulatory molecules; immunoglobulin-V; immunoglobulin-C; B7-H3 gene; genome; evolutionary analysis; mammalian genes.

DOI: 10.1504/IJDMB.2012.049247

International Journal of Data Mining and Bioinformatics, 2012 Vol.6 No.3, pp.292 - 303

Received: 23 Jun 2010
Accepted: 07 Sep 2010
Published online: 17 Dec 2014 *

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