Title: Ozone degradation of chloramphenicol: efficacy, products and toxicity

Authors: Junliang Wang; Wenshan Sun; Chao Xu; Weiping Liu

Addresses: Research Center of Environmental Science, College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China ' Research Center of Environmental Science, College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China ' Research Center of Environmental Science, College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China ' College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310012, China

Abstract: The present work investigated the ozonation of chloramphenicol (CAP). Aqueous CAP was effectively removed by ozonation. The reaction intermediates or products were identified by liquid chromatography/mass spectrometry and ion chromatography. A possible degradation scheme was proposed based on the detected products. The change of antibiotic activity and acute toxicity of reaction mixtures was evaluated using E. coli and zebrafish embryo (Danio rerio) as tested organisms, respectively. The antibiotic activity decreased after ozonation, while the acute embryo toxicity increased in the first 120-min ozonation and subsequently decreased as the reaction prolonged.

Keywords: ozone degradation; chloramphenicol; toxicity; zebrafish embryo; antibiotic activity; ozonation; E. coli.

DOI: 10.1504/IJETM.2012.047235

International Journal of Environmental Technology and Management, 2012 Vol.15 No.2, pp.180 - 192

Received: 10 Jun 2011
Accepted: 13 Feb 2012
Published online: 17 Dec 2014 *

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