Title: A structural bioinformatics approach to explore the interactions of P53 and BRCA1 gene products on ovarian and breast cancer

Authors: Satyajeet Parija, Amit Kumar

Addresses: BioAxis DNA Research Centre Pvt. Ltd., 3/154, Vikas Khand, Gomtinagar Lucknow, 226010, UP, India; and Rayalaseema University Kurnool, Andhra Pradesh, India. ' BioAxis DNA Research Centre Pvt. Ltd., 12-13-1249, 1st Floor, Beside Andhra Bank, Tarnaka, Secunderabad – 500017, India

Abstract: A vast majority of the ovarian and the breast cancers are sporadic and result from the accumulation of genetic damage. Most preclinical data suggest that women experiencing ovarian cancer are prone to breast cancer and vice versa. Similar domains and similar binding sites often imply similar protein–protein interactions and similar functions. Zinc finger of P53 and Ring finger of BRCA1 are similar domains having mostly binding activity. BRCT domain of BRCA1 is helpful in DNA-damage repair and cell cycle checkpoint functioning. This study sets out to check similar pattern, domain and residue-specific mutation, which may interact with expressions of P53 and BRCA1.

Keywords: breast cancer; ovarian cancer; BRCA1 mutations; P53 mutations; structural bioinformatics.

DOI: 10.1504/IJBRA.2011.039166

International Journal of Bioinformatics Research and Applications, 2011 Vol.7 No.1, pp.1 - 14

Published online: 24 Jan 2015 *

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