Title: A systematic in-vitro and in-silico approaches on evaluation of commercially available Metformin Hcl tablets

Authors: R. Seenivasagam, K. Hemavathi

Addresses: Department of Pharmacoinformatics, Outsource Bioinformatics, Development Center, Grand Residency, Bangalore 560 078, India. ' Department of Bioinformatics, School of Chemical & Biotechnology, Sastra University, Thanjore, Tamil Nadu 613 402, India

Abstract: The main objectives of the investigational study are in-vitro and in-vivo evaluation of Metformin Hcl tablets on Non-Insulin Dependent Diabetic Mellitus (NIDDM). Various tablet parameters were evaluated through in-vitro tests on marketed brands of Metformin Hcl tablets. The results obtained earlier are correlated with variation in dissolution profiles the dissolution profiles of the marketed brands with regard to any possible bio-equivalence are analysed. In-silico studies are important to locate molecular targets for NIDDM. Through homology modelling and active-site prediction, the suitable protein and receptor for Metformin Hcl were identified.

Keywords: Metformin tablets; pharmacoinformatics; anti-diabetics; in-silico analysis; molecular docking; drug informatics; drugs; diabetes mellitus type 2; non-insulin-dependent diabetes mellitus; molecular targets; homology modelling; active-site prediction; proteins; receptors.

DOI: 10.1504/IJFIPM.2010.039120

International Journal of Functional Informatics and Personalised Medicine, 2010 Vol.3 No.3, pp.204 - 214

Received: 01 Apr 2010
Accepted: 23 May 2010
Published online: 17 Mar 2011 *

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