Title: Nanopharmaceuticals I: nanocarrier systems in drug delivery
Author: Yun-Seok Rhee, Heidi M. Mansour
Department of Pharmaceutical Sciences, Drug Development Division, University of Kentucky College of Pharmacy, 789 South Limestone Street, Lexington, KY 40536-0596, USA.
Department of Pharmaceutical Sciences, Drug Development Division, University of Kentucky College of Pharmacy, 789 South Limestone Street, Lexington, KY 40536-0596, USA
Journal: Int. J. of Nanotechnology, 2011 Vol.8, No.1/2, pp.84 - 114
Abstract: To achieve maximum pharmacological effects with minimum side effects of drugs, drugs should be delivered to target sites without significant distribution to non-target areas. Using pharmaceutical nanocarrier systems for drug delivery is a useful delivery platform for improving target specificity, therapeutic activity, and reducing toxicity of drugs. Various sophisticated nanocarrier systems have been developed for drug delivery, and this review focuses on liposomes, polymeric nanoparticles, polymeric micelles, lipid nanoparticles, microemulsions, nanogels, and submicron lipid emulsions. This review outlines and explores nanocarrier systems for drug delivery by various administration routes including parenteral, oral, transdermal, pulmonary, ocular, and mucosal and discusses the product development and related issues in nanopharmaceutical drug delivery.
Keywords: liposomes; polymeric nanoparticles; polymeric micelles; lipid nanoparticles; microemulsions; nanogels; submicron lipid emulsions; nanopharmaceuticals; nanocarrier systems; drug delivery; nanotechnology; target specificity; therapeutic activity; toxicity.
Available online 30 Nov 2010