Title: Study of delayed effects induced by accelerated ¹²C ions with an energy of 200 MeV/n and X-rays on mice in vivo

Authors: Svetlana I. Zaichkina, Olga M. Rozanova, Helena N. Smirnova, Sergey N. Romanchenko, Alexander E. Shemyakov, Valentina N. Maltseva, Vladimir E. Balakin, Jan Ruzicka

Addresses: Institute of Theoretical and Experimental Biophysics, Moscow region, Pushchino 142290, Russia. ' Institute of Theoretical and Experimental Biophysics, Moscow region, Pushchino 142290, Russia. ' Institute of Theoretical and Experimental Biophysics, Moscow region, Pushchino 142290, Russia. ' Institute of Theoretical and Experimental Biophysics, Moscow region, Pushchino 142290, Russia. ' Physical Technical Center, Lebedev Physical Institute, Moscow region, Protvino, Russia. ' Physical Technical Center, Lebedev Physical Institute, Moscow region, Protvino, Russia. ' Physical Technical Center, Lebedev Physical Institute, Moscow region, Protvino, Russia. ' Slovak Office of Standards, Metrology and Testing, Stefanovicova 3, Bratislava, Slovakia

Abstract: In the present work, we investigated the delayed effects induced by accelerated ¹²C ions with energy of 200 MeV/n and X-rays on mice. Dose dependence, ability of the adaptive response (AR) induction and genomic instability in F1 generation were studied by the micronucleus test in polychromatic erythrocytes in bone marrow. Irradiation by carbon ions with doses of 0.1, 0.2, 0.5, 1 and 1.5 Gy was induced by the accelerator |Nuclotron| and irradiation by X-rays with the same doses – on the RUM device. The experiments demonstrated that (a) at low doses (0–0.5 Gy), both dose dependences of cytogenetic damage induction can be fitted by a linear regression and almost coincide, (b) both these types of radiation induce AR and (c) they lead to an increase in sensitivity to additional irradiation with a dose of 1.5 Gy of X-radiation and the absence of AR in the F1 generation.

Keywords: accelerated carbon ions; high-LET radiation; low dose radiation; micronucleus test; adaptive response; genetic instability; x-rays; mice; dose dependence; genomic instability; polychromatic erythrocytes; bone marrow; irradiation; low radiation; cytogenetic damage.

DOI: 10.1504/IJLR.2010.034915

International Journal of Low Radiation, 2010 Vol.7 No.4, pp.268 - 275

Published online: 30 Aug 2010 *

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