Title: Cellular defence mechanisms: modelling of the DSB generation and repair process under ion radiation

Authors: Jinpeng Qi, Shihuang Shao, Hui Bai, Doudou Li

Addresses: College of Information Sciences and Technology, Donghua University, Shanghai 201620, P.R. China. ' No. 2999, North Renmin Road, Songjiang District, Shanghai, 201620, China. ' No. 2999, North Renmin Road, Songjiang District, Shanghai, 201620, China. ' No. 2999, North Renmin Road, Songjiang District, Shanghai, 201620, China

Abstract: Cells can trigger self-defence mechanisms in response to acute perturbations from outside. To investigate the complicated mechanisms of cellular response to continuous Ion Radiation (IR) at the single-cell level, a model of the Double Strand Breaks (DSBs) generation and repair process is proposed. The model can be successfully used to simulate the investigation of the stochastic traces of DSBs generation, as well as the different kinetics of the complicated interactions among resulting DSBs, DSB-protein Complexes (DSBCs), Repair Protein (RP), and misrepair of DSBs (Fw) under different radiation dose domains.

Keywords: DNA damage; ionising radiation; P53; signal pathway; modelling; cellular defence mechanisms; double strand breaks; kinetics; radiation doses; low radiation; DSB generation; DSB repair.

DOI: 10.1504/IJLR.2008.018816

International Journal of Low Radiation, 2008 Vol.5 No.1, pp.37 - 48

Published online: 18 Jun 2008 *

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