Title: Biosensor with total internal reflection imaging ellipsometry

Authors: Y-Y. Chen, Z-H. Wang, Y-H. Meng, G. Jin

Addresses: Institute of Mechanics, Chinese Academy of Sciences, #15, Bei-si-huan West Rd., Beijing 100080, P.R. China; Graduate School of Chinese Academy of Sciences, #19, Yu-quan Rd, Shi-jing-shan District, Beijing 100039, P.R. China. ' Institute of Mechanics, Chinese Academy of Sciences, #15, Bei-si-huan West Rd., Beijing 100080, P.R. China. ' Institute of Mechanics, Chinese Academy of Sciences, #15, Bei-si-huan West Rd., Beijing 100080, P.R. China; Graduate School of Chinese Academy of Sciences, #19, Yu-quan Rd, Shi-jing-shan District, Beijing 100039, P.R. China. ' Institute of Mechanics, Chinese Academy of Sciences, #15, Bei-si-huan West Rd., Beijing 100080, P.R. China

Abstract: In order to monitor multiple protein reaction processes simultaneously, a biosensor based on imaging ellipsometry operated in the total internal reflection mode is proposed. It could be realised as an automatic analysis for protein interaction processes with real-time label-free method. Its principle and methodology as well as a demonstration for its applications are presented.

Keywords: biosensors; imaging ellipsometry; total internal reflection; micro-arrays; nanotechnology; multiple protein reaction; protein interactions; micro-fluidic systems; kinetic measurement; multiple biomolecule reactions.

DOI: 10.1504/IJNT.2007.012322

International Journal of Nanotechnology, 2007 Vol.4 No.1/2, pp.171 - 178

Published online: 05 Feb 2007 *

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