A system biology approach for understanding the miRNA regulatory network in colon rectal cancer Online publication date: Wed, 17-Dec-2014
by Meeta Pradhan; Kshithija Nagulapalli; Lakenvia Ledford; Yogesh Pandit; Mathew Palakal
International Journal of Data Mining and Bioinformatics (IJDMB), Vol. 11, No. 1, 2015
Abstract: In this paper we present a systems biology approach to the understanding of the miRNA-regulatory network in colon rectal cancer. An initial set of significant genes in Colon Rectal Cancer (CRC) were obtained by mining relevant literature. An initial set of cancer-related miRNAs were obtained from three databases: miRBase, miRWalk, Targetscan and GEO microarray experiment. First principle methods were then used to generate the global miRNA-gene network. Significant miRNAs and associated transcription factors in the global miRNA-gene network were identified using topological and sub-graph analyses. Eleven novel miRNAs were identified and three of the novel miRNAs, hsa-miR-630, hsa-miR-100 and hsa-miR-99a, were further analysed to elucidate their role in CRC. The proposed methodology effectively made use of literature data and was able to show novel, significant miRNA-transcription associations in CRC.
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