Immobilising of anti-HPV18 and E. coli O157:H7 antibodies on magnetic silica-coated Fe3O4 for early diagnosis of cervical cancer and diarrhoea
by Tran Hoang Hai, Le Hong Phuc, Le Khanh Vinh, Bui Duc Long, Truong Thuy Kieu, Nguyen Ngoc Bich, Tran Nguyen Lan, Nguyen Quan Hien, Le Hoang Anh Khoa, Nguyen Ngoc Van Tam
International Journal of Nanotechnology (IJNT), Vol. 8, No. 3/4/5, 2011

Abstract: This paper presents the synthesis and properties of magnetic silica-coated Fe3O4 nanoparticles. Uncoated Fe3O4 nanoparticles with an average diameter of 9-16 nm and saturation magnetisation of around 66 emu/g were first prepared by co-precipitation method. After being coated by SiO2 using the sol-gel method, the diameters of the coated particles ranged from 29 nm to 230 nm and their corresponding saturation magnetisation was reduced to 29 emu/g. The magnetic coated nanoparticles were attached to the monoclonal antibodies of HPV18 and E. coli O157:H7. The TG/DTA analyses indicated that antibodies were attached to the magnetic nanoparticles. The obtained results revealed that magnetic SiO2-coated Fe3O4 nanoparticles can be a promising candidate for the diagnosis of cervical cancer at an early stage with high accuracy.

Online publication date: Fri, 21-Jan-2011

The full text of this article is only available to individual subscribers or to users at subscribing institutions.

 
Existing subscribers:
Go to Inderscience Online Journals to access the Full Text of this article.

Pay per view:
If you are not a subscriber and you just want to read the full contents of this article, buy online access here.

Complimentary Subscribers, Editors or Members of the Editorial Board of the International Journal of Nanotechnology (IJNT):
Login with your Inderscience username and password:

    Username:        Password:         

Forgotten your password?


Want to subscribe?
A subscription gives you complete access to all articles in the current issue, as well as to all articles in the previous three years (where applicable). See our Orders page to subscribe.

If you still need assistance, please email subs@inderscience.com