Molecular modelling insights into DFNA15 mediated enhancement of POU4F3 stability Online publication date: Wed, 26-Nov-2008
by Christopher M. Frenz, Philippe P. Lefebvre
International Journal of Computational Biology and Drug Design (IJCBDD), Vol. 1, No. 3, 2008
Abstract: The POU4F3 transcription factor is expressed in the cochlear and vestibular hair cells of the inner ear and its targeted deletion results in a loss of inner ear hair cells. The DFNA15 truncation mutation has been demonstrated to result in a loss of transcriptional activity, but an increase in the stability of the protein. Molecular modelling is utilised to propose a mechanism of stability enhancement, via an interaction between the truncated POUHD domain and the POUS domain of the transcription factor.
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