Biocompatibility conditions and biological activity of cobalt nanoparticles, depending on the size and concentration
by D.G. Churilov; S.D. Polischuk; V.V. Churilova; G.I. Churilov; S.N. Borychev; I.S. Arapov
International Journal of Nanotechnology (IJNT), Vol. 16, No. 6/7/8/9/10, 2019

Abstract: Biological activity, the effect of 'small doses' and the biocompatibility of cobalt nanoparticles (NP) have been studied and proved, depending on the size and concentration of NP on white mustard. For nanoparticles with a particle size of 18-60 nm, the dependence of enzyme activity on concentration has general regularities and is consistent with the observed effect of 'small doses' in determining morpho-physiological parameters. Nanoparticles sized up to 20 nm show high activity at low concentrations up to the maximum concentration of 10 g/t. For nanoparticles with a size of 35-60 nm the concentration limit is much higher than 100 g/t. We assume that cobalt nanoparticles are a source of some additional amount of protons, which leads to a change in the hormonal status, stimulates or reduces the activity of certain endogenous phytohormones, depending on the size, physical and chemical characteristics of nanoparticles and concentration. Biologically active nanoparticles, acting on the level of phytohormones, indolylacetic acid (IAA) in particular, can influence the state of bio membranes and indirectly act as a regulator of protein-synthesising plant cells. This leads to the growth and development of living systems. The comprehensive study of the effect of different concentrations and sizes of nanoparticles on the activity of three antioxidant enzymes (SOD, catalase and peroxidase) has made it possible to establish that the peroxidase activity at maximum morpho-physiological parameters is high and decreases in 'dead zones' at both low and high concentrations of metal nanoparticles. The activity of SOD and catalase in the studied cultures decreased significantly under the conditions of maximum morpho-physiological parameters and sharply increased at concentrations greater than 100 g/t for nanoparticles 35-60 nm in size and above 10 g/t with a size of up to 20 nm. The conditions of biocompatibility of cobalt nanoparticles are shown.

Online publication date: Wed, 15-Apr-2020

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