Most recent issue published online in the International Journal of Nanoparticles.
International Journal of Nanoparticles
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International Journal of Nanoparticles
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International Journal of Nanoparticles
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http://www.inderscience.com/browse/index.php?journalID=241&year=2023&vol=15&issue=1
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Synergistic antibacterial effect against S. Aureus in combination with amoxicillin using fluconazole nanoparticles studied under atomic force microscopy
http://www.inderscience.com/link.php?id=135748
COVID-19 patients are increasing day by day. The risk of bacteria-virus co-infection also escalates. Antibiotic resistance caused by pathogenic bacteria has become a major health challenge these days. The key objective was to examine the antibacterial effects of Fluconazole coated silver nanoparticles (Ful-AgNPs) in combination with amoxicillin against bacteria that show resistance to amoxicillin. Here we report quick, and feasible synthetic procedure for the preparation of Ful-AgNPs. Characterisation of nanoparticles was performed by employing Uv, FTIR, and AFM techniques. The size of Ful-AgNPs found in the range from 9-18 nm. Fractional inhibitory concentration index showed synergistic interaction of Ful-AgNPs with amoxicillin with effective inhibitory values found to be 25-50 μg while MIC for amoxicillin alone was found to be 75 μg. Bioassay conducted via AFM along with classical bioassay that supports the synergistic effect of Ful-AgNPs on the antibacterial activity of amoxicillin. Synthesised nanoparticles have found nontoxic against human mononuclear macrophages.
Synergistic antibacterial effect against S. Aureus in combination with amoxicillin using fluconazole nanoparticles studied under atomic force microscopy
Dania Ahmed; Samina Perveen; Muhammad Raza Shah; Farid Ahmed
International Journal of Nanoparticles, Vol. 15, No. 1 (2023) pp. 1 - 17
COVID-19 patients are increasing day by day. The risk of bacteria-virus co-infection also escalates. Antibiotic resistance caused by pathogenic bacteria has become a major health challenge these days. The key objective was to examine the antibacterial effects of Fluconazole coated silver nanoparticles (Ful-AgNPs) in combination with amoxicillin against bacteria that show resistance to amoxicillin. Here we report quick, and feasible synthetic procedure for the preparation of Ful-AgNPs. Characterisation of nanoparticles was performed by employing Uv, FTIR, and AFM techniques. The size of Ful-AgNPs found in the range from 9-18 nm. Fractional inhibitory concentration index showed synergistic interaction of Ful-AgNPs with amoxicillin with effective inhibitory values found to be 25-50 μg while MIC for amoxicillin alone was found to be 75 μg. Bioassay conducted via AFM along with classical bioassay that supports the synergistic effect of Ful-AgNPs on the antibacterial activity of amoxicillin. Synthesised nanoparticles have found nontoxic against human mononuclear macrophages.]]>
10.1504/IJNP.2023.135748
International Journal of Nanoparticles, Vol. 15, No. 1 (2023) pp. 1 - 17
Dania Ahmed
Samina Perveen
Muhammad Raza Shah
Farid Ahmed
International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 74500, Pakistan ' International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 74500, Pakistan ' International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 74500, Pakistan ' International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 74500, Pakistan
silver nanoparticles
antibacterial potential
UV-visible spectroscopy
amoxicillin
synergistic effect
combinatorial effect
COVID-19
2024-01-04T23:20:50-05:00
Copyright © 2024 Inderscience Enterprises Ltd.
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A combination of carrier erythrocytes and artificial nanoparticles as a promising approach for drug delivery: a review
http://www.inderscience.com/link.php?id=135767
The need for extensive drug delivery research was fuelled by the increasing awareness of how drug release patterns affect therapeutic responses and the necessity for safe and efficient drug administration. Scientists understood that novel therapies are possible when a drug is encapsulated within or attached to a carrier. It has thus become clear that drug carrier systems are essential as the drug itself. Nanotechnology's applications in drug delivery have been reported to improve therapeutic outcomes. Nevertheless, challenges related to biocompatibility, cytotoxicity, and rapid clearance have limited the use of nanomedicine. After extensive research, erythrocyte membrane camouflaged nanoparticles loaded with drugs have become an attractive candidate for drug delivery. This strategy has offered an opportunity to unite the properties of natural cell membrane with that of nanoparticles. This paper reviews the development and importance of the combined strategy and provides a foundation to stimulate the interest in this novel strategy.
A combination of carrier erythrocytes and artificial nanoparticles as a promising approach for drug delivery: a review
Nadeesha Athukorala; Sanath Rajapakse; S.D.S.S. Sooriyapathirana
International Journal of Nanoparticles, Vol. 15, No. 1 (2023) pp. 18 - 40
The need for extensive drug delivery research was fuelled by the increasing awareness of how drug release patterns affect therapeutic responses and the necessity for safe and efficient drug administration. Scientists understood that novel therapies are possible when a drug is encapsulated within or attached to a carrier. It has thus become clear that drug carrier systems are essential as the drug itself. Nanotechnology's applications in drug delivery have been reported to improve therapeutic outcomes. Nevertheless, challenges related to biocompatibility, cytotoxicity, and rapid clearance have limited the use of nanomedicine. After extensive research, erythrocyte membrane camouflaged nanoparticles loaded with drugs have become an attractive candidate for drug delivery. This strategy has offered an opportunity to unite the properties of natural cell membrane with that of nanoparticles. This paper reviews the development and importance of the combined strategy and provides a foundation to stimulate the interest in this novel strategy.]]>
10.1504/IJNP.2023.135767
International Journal of Nanoparticles, Vol. 15, No. 1 (2023) pp. 18 - 40
Nadeesha Athukorala
Sanath Rajapakse
S.D.S.S. Sooriyapathirana
Faculty of Science, Department of Molecular Biology and Biotechnology, University of Peradeniya, Peradeniya, 20400, Sri Lanka ' Faculty of Science, Department of Molecular Biology and Biotechnology, University of Peradeniya, Peradeniya, 20400, Sri Lanka ' Faculty of Science, Department of Molecular Biology and Biotechnology, University of Peradeniya, Peradeniya, 20400, Sri Lanka
erythrocytes
nanoparticles
drug delivery
carrier erythrocytes
membrane
nanocarriers
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Copyright © 2024 Inderscience Enterprises Ltd.
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Characterisation and biological activity of rare-earth ion (Ce3+)-doped ZnO nanoparticles
http://www.inderscience.com/link.php?id=135768
Zn<SUB align="right">1-xCe<SUB align="right">xO nanoparticles with x = 0, 0.01, 0.03, 0.05 and 0.07 were synthesised using a chemical co-precipitation method. The effects of Ce<SUP align="right">3+</SUP>doping on the properties of zinc oxide (ZnO) nanoparticles were studied. The prepared nanoparticles were characterised by X-ray diffraction, transmission electron microscopy, Fourier transform infrared spectroscopy, photoluminescence spectroscopy (PL), UV-visible spectroscopy and vibrating sample magnetometry. The CeO<SUB align="right">2secondary phase induced structural and morphological changes. The Zn-O stretching peak shifted slightly due to the inclusion of Ce<SUP align="right">3+</SUP> ions into the ZnO matrix. PL spectroscopy revealed minor defects and a direct bandgap of 2.81-3.15 eV. The samples exhibited diamagnetic behaviour with a ferromagnetic contribution at room temperature. The prepared samples were assessed for their antibacterial efficiency against six bacterial strains using the agar well diffusion method.
Characterisation and biological activity of rare-earth ion (Ce3+)-doped ZnO nanoparticles
Maryam Al Bitar; Mahmoud Khalil; R. Awad
International Journal of Nanoparticles, Vol. 15, No. 1 (2023) pp. 41 - 67
Zn<SUB align="right">1-xCe<SUB align="right">xO nanoparticles with x = 0, 0.01, 0.03, 0.05 and 0.07 were synthesised using a chemical co-precipitation method. The effects of Ce<SUP align="right">3+</SUP>doping on the properties of zinc oxide (ZnO) nanoparticles were studied. The prepared nanoparticles were characterised by X-ray diffraction, transmission electron microscopy, Fourier transform infrared spectroscopy, photoluminescence spectroscopy (PL), UV-visible spectroscopy and vibrating sample magnetometry. The CeO<SUB align="right">2secondary phase induced structural and morphological changes. The Zn-O stretching peak shifted slightly due to the inclusion of Ce<SUP align="right">3+</SUP> ions into the ZnO matrix. PL spectroscopy revealed minor defects and a direct bandgap of 2.81-3.15 eV. The samples exhibited diamagnetic behaviour with a ferromagnetic contribution at room temperature. The prepared samples were assessed for their antibacterial efficiency against six bacterial strains using the agar well diffusion method.]]>
10.1504/IJNP.2023.135768
International Journal of Nanoparticles, Vol. 15, No. 1 (2023) pp. 41 - 67
Maryam Al Bitar
Mahmoud Khalil
R. Awad
Faculty of Science, Department of Physics, Beirut Arab University, Beirut, 1107 2809, Lebanon ' Department of Biological Sciences, Faculty of Science, Beirut Arab University, Beirut, 1107 2809, Lebanon; Faculty of Science, Department of Zoology, Molecular Biology Unit, Alexandria University, Alexandria, 21568, Egypt ' Faculty of Science, Department of Physics, Beirut Arab University, Beirut, 1107 2809, Lebanon
zinc oxide nanoparticles
cerium-doping
co-precipitation technique
biological activity
2024-01-04T23:20:50-05:00
Copyright © 2024 Inderscience Enterprises Ltd.
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67
2024-01-04T23:20:50-05:00
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Development of silver nanoparticles using trigonella foenum graecum leaf extract and evaluation of their antimicrobial and noncytotoxic efficacy for dental applications
http://www.inderscience.com/link.php?id=135770
This study explores the use of nanotechnology in addressing the emerging challenges of denture-related infections, particularly denture stomatitis, which is prevalent among geriatric patients with limited manual dexterity. The objective is to develop new bioactive compounds to combat microbial resistance. Silver nanoparticles were synthesised using an extract derived from Trigonella foenum graecum and characterised using various techniques. The antimicrobial activity of the nanoparticles against key microorganisms associated with denture stomatitis was evaluated, along with their cytotoxic effects on fibroblast cell lines. The results demonstrated that the synthesised nanoparticles exhibited high effectiveness against the tested microorganisms while displaying no significant cytotoxicity at bactericidal doses. These findings suggest that silver nanoparticles have substantial potential as antimicrobial additives in the fabrication process of acrylic dentures.
Development of silver nanoparticles using trigonella foenum graecum leaf extract and evaluation of their antimicrobial and noncytotoxic efficacy for dental applications
Lata S. Mushannavar; Ramesh K. Nadiger; M.Y. Kariduraganavar; Kiran Kumar Neelakantappa; Sachin Hegde
International Journal of Nanoparticles, Vol. 15, No. 1 (2023) pp. 68 - 85
This study explores the use of nanotechnology in addressing the emerging challenges of denture-related infections, particularly denture stomatitis, which is prevalent among geriatric patients with limited manual dexterity. The objective is to develop new bioactive compounds to combat microbial resistance. Silver nanoparticles were synthesised using an extract derived from Trigonella foenum graecum and characterised using various techniques. The antimicrobial activity of the nanoparticles against key microorganisms associated with denture stomatitis was evaluated, along with their cytotoxic effects on fibroblast cell lines. The results demonstrated that the synthesised nanoparticles exhibited high effectiveness against the tested microorganisms while displaying no significant cytotoxicity at bactericidal doses. These findings suggest that silver nanoparticles have substantial potential as antimicrobial additives in the fabrication process of acrylic dentures.]]>
10.1504/IJNP.2023.135770
International Journal of Nanoparticles, Vol. 15, No. 1 (2023) pp. 68 - 85
Lata S. Mushannavar
Ramesh K. Nadiger
M.Y. Kariduraganavar
Kiran Kumar Neelakantappa
Sachin Hegde
Department of Prosthodontics, SDM College of Dental Sciences and Hospital, Sattur, Dharwad, 580009, Karnataka, India ' Department of Prosthodontics, SDM College of Dental Sciences and Hospital, Sattur, Dharwad, 580009, Karnataka, India ' Department of Chemistry, Karnatak University, Dharwad, 580003, Karnataka, India ' Department of Conservative Dentistry, Government Dental College and Research Institute, Bengaluru, 560002, Karnataka, India ' Department of Chemistry, Karnatak University, Dharwad, 580003, Karnataka, India
silver nanoparticles
denture stomatitis
trigonella foenum graecum
antimicrobial activity
cytotoxicity
2024-01-04T23:20:50-05:00
Copyright © 2024 Inderscience Enterprises Ltd.
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68
85
2024-01-04T23:20:50-05:00